Paola Martinelli Selected Research

Neoplasms (Cancer)

1/2023	Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments.
7/2020	Clinical and Pre-Clinical Evidence of Carbonic Anhydrase IX in Pancreatic Cancer and Its High Expression in Pre-Cancerous Lesions.
1/2020	ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity.
1/2019	Mouse Models Shed Light on the SLIT/ROBO Pathway in Pancreatic Development and Cancer.
1/2019	The Anthrax Toxin Receptor 1 (ANTXR1) Is Enriched in Pancreatic Cancer Stem Cells Derived from Primary Tumor Cultures.
1/2019	Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance.
1/2017	GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.
3/2016	The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.
11/2014	Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.
10/2014	BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.

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Paola Martinelli Research Topics

Disease

13	Neoplasms (Cancer) 01/2023 - 10/2005
4	Pancreatic Neoplasms (Pancreatic Cancer) 07/2020 - 11/2014
3	Adenocarcinoma 01/2023 - 03/2016
3	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2016 - 01/2010
2	Carcinogenesis 01/2022 - 11/2014
2	Hereditary Spastic Paraplegia 12/2016 - 10/2011
1	Neoplasm Metastasis (Metastasis) 01/2023
1	Acidosis 07/2020
1	Hypoxia (Hypoxemia) 07/2020
1	Necrosis 07/2020
1	Breast Neoplasms (Breast Cancer) 01/2020
1	Metaplasia 11/2018
1	Inflammation (Inflammations) 01/2018
1	Pancreatitis 01/2018
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 12/2016
1	Demyelinating Diseases (Demyelinating Disease) 12/2016
1	Adenoma (Adenomas) 07/2014
1	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2012
1	Spastic Ataxia 10/2011
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 06/2011
1	Lymphoma (Lymphomas) 06/2011
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2006

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2011
3	m-AAA proteasesIBA 12/2016 - 01/2010
2	Messenger RNA (mRNA)IBA 01/2018 - 01/2011
2	NucleophosminIBA 03/2006 - 10/2005
1	Nucleosomes (Nucleosome)IBA 01/2023
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2023
1	Proteolysis Targeting ChimeraIBA 01/2023
1	Transcription Factors (Transcription Factor)IBA 01/2023
1	CollagenIBA 01/2023
1	Recombinases (Recombinase)IBA 01/2022
1	MucinsIBA 07/2020
1	Carbonic Anhydrase IXIBA 07/2020
1	Hormones (Hormone)IBA 01/2020
1	PlasticsIBA 01/2020
1	Clodronic Acid (Clodronate)IBA 01/2019
1	Axl Receptor Tyrosine KinaseIBA 01/2019
1	Roundabout ProteinsIBA 01/2019
1	anthrax toxin receptorsIBA 01/2019
1	Liposomes (Liposome)IBA 01/2019
1	Gemcitabine FDA Link 01/2019
1	Serotonin (5 Hydroxytryptamine)IBA 11/2018
1	rac1 GTP-Binding ProteinIBA 11/2018
1	Monomeric GTP-Binding ProteinsIBA 11/2018
1	GATA Transcription FactorsIBA 01/2017
1	ChromatinIBA 03/2016
1	RNA (Ribonucleic Acid)IBA 03/2016
1	Metformin (Glucophage)FDA LinkGeneric 11/2014
1	Nicotine FDA Link 11/2014
1	CaspasesIBA 10/2014
1	X-Linked Inhibitor of Apoptosis ProteinIBA 10/2014
1	GATA6 Transcription FactorIBA 07/2014
1	Dynamins (Dynamin)IBA 01/2012
1	ProhibitinsIBA 01/2012
1	GTP Phosphohydrolases (GTPases)IBA 01/2012
1	IsoenzymesIBA 10/2011
1	Anaplastic Lymphoma KinaseIBA 06/2011
1	Culture MediaIBA 01/2011
1	AgarIBA 01/2011
1	Peptide Hydrolases (Proteases)FDA Link 01/2010
1	DNA (Deoxyribonucleic Acid)IBA 10/2005
1	PhosphoproteinsIBA 10/2005

Therapy/Procedure

3	Therapeutics 07/2020 - 01/2019
1	Drug Therapy (Chemotherapy) 01/2019
1	Adjuvant Chemotherapy 01/2017